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Click on the phrases to see them in context. The original texts by Immanuel Kant and David Hume are available from the Gutenberg Projet.

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This connection can be hoped for only on the assumption that the cause of nature is a supreme reason, which governs according to moral laws.

 Here then is the proper business of municipal laws, to fix what the principles of human nature have left undetermined. 
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 But when we consider the same actions in relation to reason--not for the purpose of explaining their origin, that is, in relation to speculative reason, but to practical reason, as the producing cause of these actions--we shall discover a rule and an order very different from those of nature and experience. But since the moral law is binding on each individual in the use of his freedom of volition, even if others should not act in conformity with this law, neither the nature of things, nor the causality of actions and their relation to morality, determine how the consequences of these actions will be related to happiness; and the necessary connection of the hope of happiness with the unceasing endeavour to become worthy of happiness, cannot be cognized by reason, if we take nature alone for our guide. I know no investigations more necessary for a full insight into the nature of the faculty which we call understanding, and at the same time for the determination of the rules and limits of its use, than those undertaken in the second chapter of the "Transcendental Analytic," under the title of "Deduction of the Pure Conceptions of the Understanding"; and they have also cost me by far the greatest labour--labour which, I hope, will not remain uncompensated. 
Human Nature is the only science of man; and yet has been hitherto the most neglected.
 Of this kind I assert justice to be; and shall endeavour to defend this opinion by a short, and, I hope, convincing argument, before I examine the nature of the artifice, from which the sense of that virtue is derived.